Biotts is pleased to announce the publication of a new peer-reviewed study in Pharmaceutics (MDPI), a leading international journal in pharmaceutical sciences.
The paper, titled “Dermal Concentration Versus Systemic Bioavailability of Topical Lidocaine and Tetracaine: An Exploratory Pharmacokinetic Pilot Study in Göttingen Minipigs”, examines the pharmacokinetic behaviour of two well-established local anaesthetics delivered via Biotts’ proprietary MTC-Y™ carrier technology.
The study focuses on a clinically relevant question: how much of a topically applied active substance reaches the skin tissue versus the systemic circulation. Using a validated Göttingen minipig model, the research provides pharmacokinetic data demonstrating that MTC-Y enhances skin permeation speed and depth compared to standard commercial formulations, while maintaining a confirmed safety profile.
This work complements Biotts’ broader research programme, which includes a completed Phase 1 clinical study for a transdermal dapagliflozin patch and ongoing development of transdermal formulations for insulin and semaglutide.
The article is published open access and available in full at Pharmaceutics 2026, 18(1), 40.
For questions about our research or partnership opportunities, please contact us at service@biotts.com.