Gottingen Mini pig study

Results

The study demonstrated the effectiveness of our transdermal insulin patch (MTC-INS) on a large animal model, comparing it to subcutaneous injection (SC).

The MTC-INS system achieved 70% of SC bioavailability, with both routes reaching peak concentrations (Cmax) at 6 hours. The transdermal administration showed sustained release, maintaining therapeutic levels longer.

Sprague Dawley rat study

Study design

The study was conducted using:
Insulin SC (Gensulin N – 0.035 mg/animal)
Transdermal MTC Carrier (insulin – 0.36 mg/animal)

The objective was to compare the insulin plasma concentration after subcutaneous administration to transdermal administration.
Male Sprague Dawley rats were employed as the animal model for this study. Plasma insulin level was measured using the ELISA method.

Results

Bioavailability of transdermal insulin administration (MTC-I) was 55.1%.

MTC-I demonstrated a more sustained release over time than Subcutaneous administration (SC), maintaining higher concentration levels for a longer duration.

A single transdermal application of insulin using the MTC carrier can sustain therapeutic concentrations for up to 5 days.